GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hif1a | increases activity | EXP | | 6480464 | CTD | Cadmium results in increased activity of HIF1A protein | PMID:33642518 | Hif1a | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HIF1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HIF1A protein | PMID:32917723 PMID:37325564 | Hif1a | increases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Cadmium results in increased expression of HIF1A mRNA; Cadmium results in increased expression of HIF1A protein | PMID:22884995 PMID:29408318 | Hif1a | multiple interactions | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]; [Cadmium Chloride results in increased abundance of Cadmium] which affects the folding of HIF1A protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of HIF1A protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HIF1A protein; Acetylcysteine inhibits the reaction [Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HIF1A mRNA]; Cadmium inhibits the reaction [Cobalt results in increased expression of HIF1A protein]; Cadmium inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; Cadmium inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EPO promoter]]; Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; MitoTEMPO inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HIF1A protein]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HIF1A protein] | PMID:10866824 PMID:29408318 PMID:29741670 PMID:32917723 PMID:35504338 | | ||||||||||||||||||||||
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