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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3a
Name: glycogen synthase kinase 3 alpha
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3aaffects response to substanceEXP 6480464CTDGSK3A protein affects the susceptibility to CadmiumPMID:27658547
Gsk3aincreases phosphorylationEXP 6480464CTDCadmium results in increased phosphorylation of GSK3A proteinPMID:27658547
Gsk3amultiple interactionsEXP 6480464CTD[Cadmium co-treated with rottlerin] results in decreased expression of GSK3A protein; GSK3A protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]; GSK3A protein affects the reaction [Cadmium results in increased expression of DDIT3 protein]; Lithium Chloride promotes the reaction [Cadmium results in increased phosphorylation of GSK3A protein]; SB 216763 promotes the reaction [Cadmium results in increased phosphorylation of GSK3A protein]PMID:27658547
Gsk3amultiple interactionsISOGSK3A (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GSK3A mRNAPMID:35301059
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