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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3713
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc5a1
Name: solute carrier family 5 member 1
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc5a1affects bindingEXP 6480464CTDCadmium binds to SLC5A1 proteinPMID:15829715
Slc5a1multiple interactionsEXP 6480464CTD[Cadmium binds to SLC5A1 protein] which affects the folding of SLC5A1 protein; Cadmium inhibits the reaction [SLC5A1 results in increased uptake of methylglucoside]PMID:15829715
Slc5a1decreases expressionISOSlc5a1 (Mus musculus)6480464CTDCadmium results in decreased expression of SLC5A1 mRNAPMID:11749115 PMID:12969150 PMID:15664265
Slc5a1multiple interactionsISOSlc5a1 (Mus musculus)6480464CTDCadmium inhibits the reaction [SP1 protein binds to SLC5A1 promoter]PMID:15664265
Slc5a1multiple interactionsISOSLC5A1 (Homo sapiens)6480464CTDCadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]; Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]PMID:20073493
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