GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Jun | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of JUN; Cadmium results in increased expression of JUN mRNA | PMID:1696944 PMID:23080431 | Jun | multiple interactions | EXP | | 6480464 | CTD | Cycloheximide promotes the reaction [Cadmium results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Cadmium results in increased expression of JUN mRNA] | PMID:1696944 | Jun | increases expression | ISO | Jun (Mus musculus) | 6480464 | CTD | Cadmium results in increased expression of JUN mRNA | PMID:15010501 PMID:26187450 | Jun | increases expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | Cadmium results in increased expression of JUN mRNA | PMID:10711420 PMID:11738272 PMID:17125913 PMID:21172416 PMID:22562489 | Jun | increases phosphorylation | ISO | JUN (Homo sapiens) | 6480464 | CTD | Cadmium results in increased phosphorylation of JUN protein | PMID:26514923 | Jun | multiple interactions | ISO | Jun (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein; [Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of JUN protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Cadmium results in increased expression of JUN mRNA] | PMID:15010501 PMID:28035397 PMID:30796935 | Jun | multiple interactions | ISO | JUN (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA; Cadmium promotes the reaction [[ESR1 protein binds to JUN protein binds to FOS protein] which binds to CXCL12 promoter]; Cadmium promotes the reaction [[ESR1 protein binds to JUN protein] which binds to CXCL12 promoter]; Cadmium promotes the reaction [ESR1 protein binds to JUN protein binds to FOS protein]; Cadmium promotes the reaction [JUN protein binds to CCND1 promoter]; Cadmium promotes the reaction [JUN protein binds to CXCL12 promoter]; Cadmium promotes the reaction [JUN protein binds to MYC promoter]; Fulvestrant inhibits the reaction [Cadmium results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of JUN protein] | PMID:17125913 PMID:24015267 PMID:26514923 PMID:35301059 | | ||||||||||||||||||||||
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