GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | increases cleavage | EXP | | 6480464 | CTD | Cadmium results in increased cleavage of PARP1 protein | PMID:29111403 | Parp1 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of PARP1 mRNA | PMID:26187450 | Parp1 | multiple interactions | EXP | | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]; bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; calpeptin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Cadmium results in increased cleavage of PARP1 protein] | PMID:29111403 PMID:30796935 PMID:37261864 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased cleavage of PARP1 protein | PMID:28507149 PMID:30985881 PMID:33857584 | Parp1 | increases cleavage | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased cleavage of PARP1 protein | PMID:19433269 PMID:23741317 PMID:25643798 PMID:27658547 PMID:33857584 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Cadmium results in increased activity of and results in increased cleavage of PARP1 protein; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; EGF protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein]; MT2A protein affects the reaction [EGF protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]]; PARP1 mutant form inhibits the reaction [Cadmium results in decreased abundance of Adenosine Triphosphate]; VMP1 affects the reaction [Cadmium results in increased cleavage of PARP1 protein]; XAF1 protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein] | PMID:21767558 PMID:24824807 PMID:28507149 PMID:29115570 PMID:30985881 | Parp1 | multiple interactions | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; Ascorbic Acid inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]; bafilomycin A promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Cadmium results in increased activity of and results in increased cleavage of PARP1 protein; Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]; GSK3A protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]; GSK3B protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]; Lithium Chloride promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]; rottlerin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; SB 216763 promotes the reaction [Cadmium results in increased cleavage of PARP1 protein] | PMID:19433269 PMID:24824807 PMID:27658547 PMID:34767868 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |