GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nqo1 | decreases expression | EXP | | 6480464 | CTD | Cadmium results in decreased expression of NQO1 mRNA | PMID:37270049 | Nqo1 | increases activity | EXP | | 6480464 | CTD | Cadmium results in increased activity of NQO1 protein | PMID:15337587 PMID:18474416 | Nqo1 | increases degradation | EXP | | 6480464 | CTD | Cadmium results in increased degradation of NQO1 mRNA | PMID:18474416 | Nqo1 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of NQO1 mRNA; Cadmium results in increased expression of NQO1 protein | PMID:15337587 PMID:16517059 PMID:18474416 PMID:26363317 PMID:34998821 | Nqo1 | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA; Cadmium inhibits the reaction [beta-Naphthoflavone results in increased expression of NQO1 mRNA]; Cadmium promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Cadmium promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; Cadmium promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Cycloheximide inhibits the reaction [Cadmium results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA] | PMID:10972992 PMID:15337587 PMID:18474416 PMID:33398418 | Nqo1 | increases activity | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased activity of NQO1 protein | PMID:17573173 | Nqo1 | increases activity | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased activity of NQO1 protein | PMID:21172416 | Nqo1 | increases expression | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased expression of NQO1 protein | PMID:22008531 | Nqo1 | increases expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased expression of NQO1 mRNA; Cadmium results in increased expression of NQO1 protein | PMID:21172416 | Nqo1 | multiple interactions | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 protein; [Cadmium co-treated with bergenin] results in increased expression of NQO1 protein; [Cadmium co-treated with galangin] results in increased expression of NQO1 protein; Ascorbic Acid promotes the reaction [Cadmium results in increased expression of NQO1 protein]; brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 protein] | PMID:22008531 PMID:34695510 PMID:35384154 PMID:37949422 | Nqo1 | multiple interactions | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA | PMID:29741670 PMID:31738976 | | ||||||||||||||||||||||
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