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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814
Species: Mus musculus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Acc ID: CHEBI:22689
Term: bafilomycin A1
Definition: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.
Chemical ID: MESH:C040929
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13509136480464CTDbafilomycin A1 results in increased expression of BNIP3 mRNA, bafilomycin A1 results in increased expression of BNIP3 protein

PMID:25981168
multiple interactionsISORGD:13509136480464CTDBNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein], Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein], gefitinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein], HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA], lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]

PMID:25981168
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.