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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10226
Species: Mus musculus
RGD Object: Gene
Symbol: Bax
Name: BCL2-associated X protein
Acc ID: CHEBI:21759
Term: N-methyl-N'-nitro-N-nitrosoguanidine
Definition: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Chemical ID: MESH:D008769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDMethylnitronitrosoguanidine results in decreased expression of BAX mRNA; Methylnitronitrosoguanidine results in decreased expression of BAX proteinPMID:20434464
Baxmultiple interactionsEXP 6480464CTDEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]PMID:20434464
Baxdecreases expressionISOBax (Rattus norvegicus)6480464CTDMethylnitronitrosoguanidine results in decreased expression of BAX proteinPMID:35103375
Baxmultiple interactionsISOBax (Rattus norvegicus)6480464CTD[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BAX protein; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]PMID:16030430 PMID:35103375
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDBAX protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]PMID:18376143
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