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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731007
Species: Mus musculus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:20993
Term: aldehydo-D-glucosamine
Definition: The open-chain form of D-glucosamine.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2multiple interactionsEXP 6480464CTDGlucosamine analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Glucosamine analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Glucosamine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone]; Glucosamine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Glucosamine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]PMID:17440993 PMID:18205790 PMID:20737476
Ptgs2decreases expressionISOPtgs2 (Rattus norvegicus)6480464CTDGlucosamine results in decreased expression of PTGS2 mRNAPMID:20737476
Ptgs2decreases glycosylationISOPTGS2 (Homo sapiens)6480464CTDGlucosamine results in decreased glycosylation of PTGS2 proteinPMID:22089456
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDGlucosamine analog results in increased expression of PTGS2 protein alternative formPMID:19656660
Ptgs2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTDGlucosamine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]PMID:20737476
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein; Glucosamine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Glucosamine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]PMID:12681956 PMID:17605605
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