GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MMP3 | decreases expression | EXP | | 6480464 | CTD | Glucosamine analog results in decreased expression of MMP3 mRNA | PMID:16300972 | MMP3 | multiple interactions | EXP | | 6480464 | CTD | [Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein; Glucosamine analog inhibits the reaction [IL1B protein results in increased expression of MMP3]; Glucosamine analog inhibits the reaction [IL1B results in increased expression of and results in increased secretion of MMP3 protein]; Glucosamine analog inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 protein]; Glucosamine results in decreased expression of and results in decreased activity of MMP3 protein | PMID:12801482 PMID:15144122 PMID:17925024 PMID:18080321 PMID:18340449 PMID:20110869 | MMP3 | increases expression | ISO | Mmp3 (Rattus norvegicus) | 6480464 | CTD | Glucosamine results in increased expression of MMP3 mRNA | PMID:17109745 | MMP3 | multiple interactions | ISO | Mmp3 (Rattus norvegicus) | 6480464 | CTD | Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]; IL1B promotes the reaction [Glucosamine results in increased expression of MMP3 mRNA] | PMID:11229466 PMID:17109745 | |
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