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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:207229
Term: dihydroartemisinin
Definition: A sesquiterpenoid compound which is used as a drug for treatment of malaria.
Chemical ID: MESH:C039060
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4multiple interactionsEXP 15036816RGDDihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine] 
Nr1h4increases expressionISONR1H4 (Homo sapiens)6480464CTDartenimol results in increased expression of NR1H4 proteinPMID:27939985
Nr1h4multiple interactionsISONR1H4 (Homo sapiens)6480464CTD[artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; artenimol inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; artenimol inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; artenimol promotes the reaction [NR1H4 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NR1H4 protein promotes the reaction [artenimol inhibits the reaction [Ethanol results in increased activity of GPT protein]]PMID:27939985
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