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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionEXP 6480464CTDAzacitidine results in increased expression of CDKN1A mRNA

PMID:21224363
Cdkn1amultiple interactionsEXP 6480464CTD[Azacitidine co-treated with entinostat] results in increased expression of CDKN1A mRNA Azacitidine inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein]

PMID:21224363 PMID:25015661
Cdkn1aincreases expressionISORGD:7353416480464CTDAzacitidine analog results in increased expression of CDKN1A protein Azacitidine results in increased expression of CDKN1A mRNA

PMID:18324645 PMID:20823114
Cdkn1amultiple interactionsISORGD:7353416480464CTD[metacept-1 co-treated with Azacitidine] results in increased expression of CDKN1A

PMID:19148494
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