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RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2amultiple interactionsISORGD:13527296480464CTD[Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA

PMID:18348204 PMID:18720364
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