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RGD ID: 3738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp1
Name: Sp1 transcription factor
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1decreases expressionISORGD:7320356480464CTDAzacitidine results in decreased expression of SP1 mRNA

Sp1multiple interactionsISORGD:113346480464CTDAzacitidine promotes the reaction [SP1 protein binds to AQP5 promoter]

Sp1multiple interactionsISORGD:7320356480464CTDAzacitidine promotes the reaction [SP1 protein binds to KIR2DL2 promoter] Azacitidine promotes the reaction [SP1 protein binds to KIR2DL4 promoter]

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