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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plcb1
Name: phospholipase C beta 1
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plcb1decreases methylationISORGD:7330946480464CTDAzacitidine results in decreased methylation of PLCB1 promoter

PMID:19805378
Plcb1decreases response to substanceISORGD:7330946480464CTDPLCB1 promoter modified form results in decreased susceptibility to Azacitidine

PMID:19805378
Plcb1increases expressionISORGD:7330946480464CTDAzacitidine results in increased expression of PLCB1 mRNA Azacitidine results in increased expression of PLCB1 protein

PMID:19805378
Plcb1increases response to substanceISORGD:7330946480464CTDPLCB1 mRNA results in increased susceptibility to Azacitidine PLCB1 protein results in increased susceptibility to Azacitidine

PMID:19805378
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