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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7355366480464CTDAzacitidine results in increased expression of KRT8 mRNA

PMID:20823114
multiple interactionsISORGD:7355366480464CTDAzacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of KRT8 mRNA]

PMID:20823114
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.