Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gadd45adecreases methylationISORGD:7338036480464CTDAzacitidine results in decreased methylation of GADD45A promoter

PMID:19190346
Gadd45aincreases expressionISORGD:7338036480464CTDAzacitidine results in increased expression of GADD45A mRNA Azacitidine results in increased expression of GADD45A protein

PMID:19190346
Gadd45amultiple interactionsISORGD:7338036480464CTD[Azacitidine results in increased expression of GADD45A protein] which results in increased susceptibility to docetaxel

PMID:19190346
Go Back to source page   Continue to Ontology report