Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2324
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2b
Name: cyclin-dependent kinase inhibitor 2B
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2baffects response to substanceISORGD:13487316480464CTDCDKN2B promoter modified form affects the susceptibility to Azacitidine

PMID:17611569
Cdkn2bdecreases methylationISORGD:13487316480464CTDAzacitidine results in decreased methylation of CDKN2B promoter

PMID:19194470
Cdkn2bmultiple interactionsISORGD:13487316480464CTD[metacept-1 co-treated with Azacitidine] results in increased expression of CDKN2B

PMID:19148494
Go Back to source page   Continue to Ontology report