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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2a
Name: cyclin-dependent kinase inhibitor 2A
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2adecreases methylationEXP 6480464CTDAzacitidine results in decreased methylation of CDKN2A gene

PMID:21224363
Cdkn2aincreases expressionEXP 6480464CTDAzacitidine results in increased expression of CDKN2A mRNA

PMID:21224363
Cdkn2amultiple interactionsEXP 6480464CTD[Azacitidine co-treated with entinostat] results in decreased methylation of CDKN2A gene [Azacitidine co-treated with entinostat] results in increased expression of CDKN2A mRNA

PMID:21224363
Cdkn2aaffects methylationISORGD:7370396480464CTDAzacitidine affects the methylation of CDKN2A gene

PMID:18443271
Cdkn2adecreases methylationISORGD:7370396480464CTDAzacitidine results in decreased methylation of CDKN2A gene

PMID:17686055
Cdkn2amultiple interactionsISORGD:103226480464CTDAzacitidine inhibits the reaction [Particulate Matter results in increased methylation of CDKN2A promoter]

PMID:22355787
Cdkn2amultiple interactionsISORGD:7370396480464CTDHydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene]

PMID:17686055
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