Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2144
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp5
Name: aquaporin 5
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp5decreases methylationISORGD:101846480464CTDAzacitidine results in decreased methylation of AQP5 promoter

PMID:17198683
Aqp5increases expressionISORGD:101846480464CTDAzacitidine results in increased expression of AQP5 protein

PMID:17198683
Aqp5multiple interactionsISORGD:101846480464CTD[Azacitidine results in decreased methylation of AQP5 promoter] which results in increased expression of AQP5 mRNA Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter]

PMID:17198683
Go Back to source page   Continue to Ontology report