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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308999
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn9
Name: claudin 9
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn9decreases methylationISORGD:13190966480464CTDAzacitidine results in decreased methylation of CLDN9 promoter

PMID:18661270
Cldn9increases expressionISORGD:13190966480464CTDAzacitidine results in increased expression of CLDN9 mRNA

PMID:18661270
Cldn9multiple interactionsISORGD:13190966480464CTD[trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN9 promoter

PMID:18661270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.