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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309875
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lig3
Name: DNA ligase 3
Acc ID: CHEBI:196991
Term: 4-hydroperoxycyclophosphamide
Definition: A phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties.
Chemical ID: MESH:C011272
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lig3decreases expressionEXP 6480464CTDperfosfamide results in decreased expression of LIG3 mRNAPMID:11754170
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