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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10896
Species: Mus musculus
RGD Object: Gene
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Acc ID: CHEBI:196991
Term: 4-hydroperoxycyclophosphamide
Definition: A phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties.
Chemical ID: MESH:C011272
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgmtdecreases expressionISOMgmt (Rattus norvegicus)6480464CTDperfosfamide results in decreased expression of MGMT mRNAPMID:11754170
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