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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:195280
Term: artemether
Definition: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.
Chemical ID: MESH:C032942
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3affects expressionISORGD:13441636480464CTDartemether affects the expression of NR1I3 mRNA alternative form

PMID:24721719
Nr1i3multiple interactionsISORGD:13441636480464CTD[Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA, Artemether binds to and results in increased activity of NR1I3 protein alternative form

PMID:31312845
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.