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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:191854
Term: arachidonyl-2'-chloroethylamide
Definition: A fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM).
Chemical ID: MESH:C119325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTDarachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:12734338
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDarachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK3 proteinPMID:26467187
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDarachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK3 proteinPMID:29033935
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDarachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 proteinPMID:19477951
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDAM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK3 protein]; arachidonyl-2-chloroethylamide promotes the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK3 protein]PMID:29033935 PMID:30607903
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