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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:18917
Term: 1,3-dichloropropan-2-ol
Definition: A secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4degreeC, boiling point 174degreeC at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose.
Chemical ID: MESH:C033489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2affects bindingEXP 6480464CTD1,3-dichloro-2-propanol binds to NFE2L2 proteinPMID:35870111
NFE2L2decreases expressionISONfe2l2 (Rattus norvegicus)6480464CTD1,3-dichloro-2-propanol results in decreased expression of NFE2L2 proteinPMID:36000575
NFE2L2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTD1,3-dichloro-2-propanol results in increased expression of NFE2L2 proteinPMID:26143167
NFE2L2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTDDimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of NFE2L2 protein]PMID:36000575
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