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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732764
Species: Homo sapiens
RGD Object: Gene
Symbol: CHRNB4
Name: cholinergic receptor nicotinic beta 4 subunit
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDNicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein], Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein], Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]

PMID:9454827
affects response to substanceISORGD:7327656480464CTDCHRNB4 protein affects the susceptibility to Nicotine

PMID:15275829
increases activityISORGD:23516480464CTDNicotine results in increased activity of CHRNB4 protein

PMID:19483072
multiple interactionsISORGD:23516480464CTDNicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein], Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]

PMID:15615518
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.