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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731058
Species: Mus musculus
RGD Object: Gene
Symbol: E2f5
Name: E2F transcription factor 5
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f5multiple interactionsISOE2F5 (Homo sapiens)6480464CTDNicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]PMID:16862215
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