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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Aincreases expressionEXP 6480464CTDNicotine results in increased expression of HIF1A proteinPMID:24793809
HIF1Amultiple interactionsEXP 6480464CTDCHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]PMID:24793809
HIF1Adecreases expressionISOHif1a (Mus musculus)6480464CTDNicotine results in decreased expression of HIF1A mRNAPMID:22687363
HIF1Amultiple interactionsISOHif1a (Mus musculus)6480464CTDresveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]PMID:22687363
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