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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDNicotine results in increased expression of CCND1 protein

PMID:15983034
decreases expressionISORGD:685576480464CTDNicotine results in decreased expression of CCND1 mRNA, Nicotine results in decreased expression of CCND1 protein

PMID:17135361, PMID:23056257
increases activityISORGD:685576480464CTDNicotine results in increased activity of CCND1 promoter

PMID:15574422
increases expressionISORGD:685566480464CTDNicotine results in increased expression of CCND1 mRNA, Nicotine results in increased expression of CCND1 protein

PMID:18448488, PMID:18805435, PMID:20061081, PMID:20106947, PMID:20727180, PMID:30836163
increases expressionISORGD:685576480464CTDNicotine results in increased expression of CCND1 protein

PMID:15574422, PMID:18835254
multiple interactionsISORGD:685566480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein], alpha-cyano-(3, 4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein], Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein], EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein], MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA], MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein], Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein], Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein], U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]

PMID:18448488, PMID:18805435, PMID:20061081, PMID:20106947, PMID:20727180, PMID:30836163
multiple interactionsISORGD:685576480464CTDDihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]

PMID:23056257
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.