GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccnd1 | increases expression | EXP | | 6480464 | CTD | Nicotine results in increased expression of CCND1 protein | PMID:15983034 PMID:34153408 | Ccnd1 | decreases expression | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of CCND1 mRNA; Nicotine results in decreased expression of CCND1 protein | PMID:17135361 PMID:23056257 | Ccnd1 | increases activity | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Nicotine results in increased activity of CCND1 promoter | PMID:15574422 | Ccnd1 | increases expression | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of CCND1 mRNA; Nicotine results in increased expression of CCND1 protein | PMID:18448488 PMID:18805435 PMID:20061081 PMID:20106947 PMID:20727180 PMID:30836163 | Ccnd1 | increases expression | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Nicotine results in increased expression of CCND1 protein | PMID:15574422 PMID:18835254 | Ccnd1 | multiple interactions | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein] | PMID:18448488 PMID:18805435 PMID:20061081 PMID:20106947 PMID:20727180 PMID:30836163 | Ccnd1 | multiple interactions | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA] | PMID:23056257 | | ||||||||||||||||||||||
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