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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316582
Species: Mus musculus
RGD Object: Gene
Symbol: Bmi1
Name: Bmi1 polycomb ring finger oncogene
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmi1increases expressionISOBMI1 (Homo sapiens)6480464CTDNicotine results in increased expression of BMI1 mRNA; Nicotine results in increased expression of BMI1 proteinPMID:23219715
Bmi1multiple interactionsISOBMI1 (Homo sapiens)6480464CTDSNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]PMID:23219715
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