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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306537
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vps28
Name: VPS28 subunit of ESCRT-I
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:15505096480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine] results in decreased expression of VPS28 mRNA, Nicotine inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of VPS28 mRNA]

PMID:20230807
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.