GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egr1 | decreases expression | EXP | | 6480464 | CTD | Nicotine results in decreased expression of EGR1 mRNA | PMID:17997037 PMID:21955143 | Egr1 | increases expression | EXP | | 6480464 | CTD | Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein | PMID:17456735 PMID:31622651 | Egr1 | multiple interactions | EXP | | 6480464 | CTD | [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EGR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EGR1 mRNA] | PMID:20230807 | Egr1 | increases expression | ISO | Egr1 (Rattus norvegicus) | 6480464 | CTD | Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein | PMID:29486207 PMID:31622651 | Egr1 | increases expression | ISO | EGR1 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein | PMID:22198237 PMID:29486207 | Egr1 | multiple interactions | ISO | EGR1 (Homo sapiens) | 6480464 | CTD | [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of EGR1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] | PMID:22198237 PMID:29486207 | | ||||||||||||||||||||||
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