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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10460
Species: Mus musculus
RGD Object: Gene
Symbol: Dbh
Name: dopamine beta hydroxylase
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dbhincreases expressionISODBH (Homo sapiens)6480464CTDNicotine results in increased expression of DBH mRNAPMID:17498763
Dbhmultiple interactionsISODBH (Homo sapiens)6480464CTD[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]PMID:17498763
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