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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550818
Species: Mus musculus
RGD Object: Gene
Symbol: Mlkl
Name: mixed lineage kinase domain-like
Acc ID: CHEBI:18721
Term: 3-chloropropane-1,2-diol
Definition: A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.
Chemical ID: MESH:D000517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mlklincreases expressionEXP 6480464CTDalpha-Chlorohydrin analog results in increased expression of MLKL mRNAPMID:29860048
Mlklmultiple interactionsEXP 6480464CTDalpha-Chlorohydrin analog results in increased expression of and results in increased phosphorylation of MLKL protein; MLKL protein affects the reaction [alpha-Chlorohydrin analog results in increased expression of CXCL1 mRNA]; MLKL protein affects the reaction [alpha-Chlorohydrin analog results in increased expression of CXCL2 mRNA]; MLKL protein affects the reaction [alpha-Chlorohydrin analog results in increased expression of IL1B mRNA]; MLKL protein affects the reaction [alpha-Chlorohydrin analog results in increased expression of IL6 mRNA]; MLKL protein affects the reaction [alpha-Chlorohydrin analog results in increased expression of TNF mRNA]PMID:29860048
Mlklincreases expressionISOMlkl (Rattus norvegicus)6480464CTDalpha-Chlorohydrin analog results in increased expression of MLKL proteinPMID:29860048
Mlklincreases phosphorylationISOMlkl (Rattus norvegicus)6480464CTDalpha-Chlorohydrin results in increased phosphorylation of MLKL proteinPMID:33187795
Mlklmultiple interactionsISOMlkl (Rattus norvegicus)6480464CTD[glycidol co-treated with alpha-Chlorohydrin] results in increased phosphorylation of MLKL proteinPMID:33187795
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