Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polg
Name: DNA polymerase gamma, catalytic subunit
Acc ID: CHEBI:18421
Term: superoxide
Definition: An oxygen radical that has formula O2.
Chemical ID: MESH:D013481
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polgincreases chemical synthesisISOPolg (Mus musculus)6480464CTDPOLG gene mutant form results in increased chemical synthesis of SuperoxidesPMID:30038268
Polgmultiple interactionsISOPolg (Mus musculus)6480464CTDMn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]PMID:30038268
Go Back to source page   Continue to Ontology report