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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:18421
Term: superoxide
Definition: An oxygen radical that has formula O2.
Chemical ID: MESH:D013481
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1decreases abundanceISOSod1 (Mus musculus)6480464CTDSOD1 protein results in decreased abundance of SuperoxidesPMID:15829915 PMID:21900685 PMID:28542246
Sod1decreases abundanceISOSOD1 (Homo sapiens)6480464CTDSOD1 protein results in decreased abundance of SuperoxidesPMID:12489993 PMID:15364863 PMID:24363997
Sod1decreases chemical synthesisISOSOD1 (Homo sapiens)6480464CTDSOD1 protein results in decreased chemical synthesis of SuperoxidesPMID:11756504
Sod1increases abundanceISOSod1 (Mus musculus)6480464CTDSOD1 protein results in increased abundance of SuperoxidesPMID:21443684
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTD[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]PMID:17391658 PMID:28542246
Sod1multiple interactionsISOSOD1 (Homo sapiens)6480464CTD[[Chelating Agents binds to Copper] which affects the activity of SOD1 protein] which results in increased abundance of Superoxides; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]PMID:12489993 PMID:18480265 PMID:24363997 PMID:31162603
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