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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1622854
Species: Mus musculus
RGD Object: Gene
Symbol: Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Acc ID: CHEBI:18421
Term: superoxide
Definition: An oxygen radical that has formula O2.
Chemical ID: MESH:D013481
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ercc6decreases abundanceISOERCC6 (Homo sapiens)6480464CTDERCC6 protein results in decreased abundance of SuperoxidesPMID:25440059
Ercc6increases abundanceISOERCC6 (Homo sapiens)6480464CTDERCC6 gene mutant form results in increased abundance of SuperoxidesPMID:25440059
Ercc6multiple interactionsISOERCC6 (Homo sapiens)6480464CTD3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]PMID:25440059
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