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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10215
Species: Mus musculus
RGD Object: Gene
Symbol: Atp7a
Name: ATPase, Cu++ transporting, alpha polypeptide
Acc ID: CHEBI:18421
Term: superoxide
Definition: An oxygen radical that has formula O2.
Chemical ID: MESH:D013481
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp7aincreases abundanceEXP 6480464CTDATP7A mutant form results in increased abundance of SuperoxidesPMID:18768397
Atp7amultiple interactionsEXP 6480464CTD[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]PMID:18768397 PMID:23884884
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