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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736015
Species: Homo sapiens
RGD Object: Gene
Symbol: ACACA
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:18406
Term: AICA ribonucleotide
Definition: A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.
Chemical ID: MESH:C031143
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACACAincreases expressionEXP 6480464CTDAICA ribonucleotide results in increased expression of ACACA protein modified formPMID:25743752
ACACAincreases phosphorylationEXP 6480464CTDAICA ribonucleotide results in increased phosphorylation of ACACA proteinPMID:15297373 PMID:16873680 PMID:20080969
ACACAincreases phosphorylationISOAcaca (Rattus norvegicus)6480464CTDAICA ribonucleotide results in increased phosphorylation of ACACA proteinPMID:16020477
ACACAmultiple interactionsISOAcaca (Mus musculus)6480464CTDAICA ribonucleotide inhibits the reaction [fipronil results in increased expression of and results in decreased phosphorylation of ACACA protein]; AICA ribonucleotide results in decreased expression of and results in increased phosphorylation of ACACA proteinPMID:27103584
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