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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551616
Species: Mus musculus
RGD Object: Gene
Symbol: Hdac5
Name: histone deacetylase 5
Acc ID: CHEBI:18406
Term: AICA ribonucleotide
Definition: A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.
Chemical ID: MESH:C031143
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac5increases phosphorylationEXP 6480464CTDAICA ribonucleotide results in increased phosphorylation of HDAC5 proteinPMID:21454484
Hdac5multiple interactionsEXP 6480464CTD[AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter]PMID:21454484
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