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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDApigenin results in decreased expression of BCL2 proteinPMID:15486995
BCL2decreases response to substanceEXP 6480464CTDBCL2 protein results in decreased susceptibility to ApigeninPMID:15486995
BCL2multiple interactionsEXP 6480464CTD[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in decreased expression of BCL2 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 proteinPMID:24070738 PMID:29247770
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]PMID:25557508 PMID:30107153 PMID:30152906 PMID:31930969 PMID:35373622
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