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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69226
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4affects bindingISOGpx4 (Mus musculus)6480464CTDApigenin binds to GPX4 proteinPMID:35500696
Gpx4increases expressionISOGpx4 (Mus musculus)6480464CTDApigenin results in increased expression of GPX4 mRNA; Apigenin results in increased expression of GPX4 proteinPMID:35500696
Gpx4multiple interactionsISOGpx4 (Mus musculus)6480464CTDApigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 protein]PMID:35500696
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