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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13500186480464CTDApigenin results in increased expression of UGT1A1 mRNA

PMID:15090468, PMID:29584932
increases glucuronidationISORGD:13500186480464CTDUGT1A1 protein results in increased glucuronidation of Apigenin

PMID:14557274
multiple interactionsISORGD:13500186480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA], [sulforafan co-treated with Apigenin] results in increased expression of UGT1A1 mRNA

PMID:15090468
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.