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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734049
Species: Homo sapiens
RGD Object: Gene
Symbol: COL1A1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:18357
Term: (R)-noradrenaline
Definition: The R-enantiomer of noradrenaline.
Chemical ID: MESH:D009638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL1A1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDNorepinephrine results in increased expression of COL1A1 mRNAPMID:10722803 PMID:14577597 PMID:19575289
COL1A1increases expressionISOCol1a1 (Mus musculus)6480464CTDNorepinephrine results in increased expression of COL1A1 mRNAPMID:34609854
COL1A1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDcarvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]; Doxazosin inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]PMID:10722803 PMID:19575289
COL1A1multiple interactionsISOCol1a1 (Mus musculus)6480464CTD[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]; FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]PMID:34609854
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