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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730870
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A1
Name: cytochrome P450 family 1 subfamily A member 1
Acc ID: CHEBI:18344
Term: kynurenic acid
Definition: A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Chemical ID: MESH:D007736
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A1increases activityEXP 6480464CTDKynurenic Acid results in increased activity of CYP1A1 proteinPMID:20106948
CYP1A1increases expressionEXP 6480464CTDKynurenic Acid results in increased expression of CYP1A1 mRNAPMID:20106948
CYP1A1multiple interactionsEXP 6480464CTD[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]PMID:20106948
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