Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:18315
Term: pyrroloquinoline quinone
Definition: A pyrroloquinoline having oxo groups at the 4- and 5-positions and carboxy groups at the 2-, 7- and 9-positions.
Chemical ID: MESH:D045542
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Aincreases expressionEXP 6480464CTDPQQ Cofactor results in increased expression of PPARGC1A mRNAPMID:28578007
PPARGC1Amultiple interactionsEXP 6480464CTDPQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]PMID:30240821
PPARGC1Aincreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDPQQ Cofactor results in increased expression of PPARGC1A mRNAPMID:25843018
PPARGC1Amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTDPQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]; PQQ Cofactor promotes the reaction [Rotenone results in increased expression of PPARGC1A mRNA]PMID:25843018 PMID:30240821
Go Back to source page   Continue to Ontology report