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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733896
Species: Mus musculus
RGD Object: Gene
Symbol: Hspd1
Name: heat shock protein 1 (chaperonin)
Acc ID: CHEBI:183083
Term: indirubin
Definition: A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by a 3-oxo-1,3-dihydro-2H-indol-2-ylidene group at position 3. It is the active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases and chronic myeloid leukemia.
Chemical ID: MESH:C027185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspd1decreases expressionISOHSPD1 (Homo sapiens)6480464CTDindirubin results in decreased expression of HSPD1 mRNAPMID:15056799
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