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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604657
Species: Homo sapiens
RGD Object: Gene
Symbol: CD40
Name: CD40 molecule
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CD40multiple interactionsEXP 6480464CTD[alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of CD40 protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 proteinPMID:11306145
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