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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10620
Species: Mus musculus
RGD Object: Gene
Symbol: Gast
Name: gastrin
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gastaffects abundanceEXP 6480464CTDGAST protein affects the abundance of HistaminePMID:12893847
Gastaffects activityEXP 6480464CTDHistamine affects the activity of GAST proteinPMID:12893847
Gastincreases secretionISOGast (Rattus norvegicus)6480464CTDGAST protein modified form results in increased secretion of Histamine; GAST protein results in increased secretion of HistaminePMID:10864877 PMID:11164953 PMID:14642791 PMID:2470453
Gastmultiple interactionsISOGast (Rattus norvegicus)6480464CTD[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]; alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine]; CXCL8 protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Dinoprostone inhibits the reaction [GAST protein results in increased secretion of Histamine]; Galanin inhibits the reaction [GAST protein results in increased secretion of Histamine]; Impromidine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine]; Pentobarbital inhibits the reaction [GAST protein results in increased secretion of Histamine]; SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Urethane inhibits the reaction [GAST protein results in increased secretion of Histamine]PMID:10864877 PMID:11164953 PMID:12190085 PMID:16378173 PMID:2470453
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